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What is PAD? Peripheral Artery Disease (PAD) is a condition where the arteries that supply blood to your limbs, typically the legs, become narrowed or blocked. This narrowing is often caused by a buildup of fatty deposits, or, plaque, in the artery walls, which can restrict blood flow and lead to various symptoms.Signs and Symptoms of PADLeg pain or cramping (especially during physical activity)Numbness or tingling in the legs or feetSores or wounds that heal slowlyColdness in the legs or f …